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Activity Number:
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8
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Type:
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Invited
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Date/Time:
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Sunday, August 3, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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ASA, Colorado-Wyoming Chapter
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| Abstract - #300367 |
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Title:
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A Modeling Framework for Evaluation and Comparison of Mp-/Id-Nat Trigger Strategies for West Nile Virus Screening
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Author(s):
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Brad Biggerstaff*+ and Lyle R. Petersen
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Companies:
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Centers for Disease Control and Prevention and Centers for Disease Control and Prevention
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Address:
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3150 Rampart Road, Fort Collins, CO, 80521,
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Keywords:
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resampling ; West Nile virus ; decision analysis
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Abstract:
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Screening of the U.S. blood supply for West Nile virus (WNV) began in 2003, shortly after transfusion-associated WNV transmission was first documented and recognition that the risk of transmission was high during seasonal outbreaks experienced in the US. Because of the seasonal nature of WNV transmission, which is a mosquito-bird-mosquito cycle in which humans intervene, during periods of low natural transmission, donations are pooled for aggregate testing, while during periods of high natural transmission, donations are tested individually. A statistical framework for evaluation and comparison of different strategies for determining when to initiate individual screening and when to revert to pooled screening is presented. This framework is used to evaluate various strategies of potential practical use under different collection center size assumptions and different epidemic conditions.
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