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Activity Number:
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428
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Type:
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Invited
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Date/Time:
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Wednesday, August 6, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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WNAR
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| Abstract - #300342 |
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Title:
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Modeling Splice-Junction Microarrays
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Author(s):
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Kasper D. Hansen*+
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Companies:
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University of California, Berkeley
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Address:
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Division of Biostatistics, School of Public Health, Berkeley, CA, 94720-7358,
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Keywords:
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microarrays ; non-linear regression
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Abstract:
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Alternative splicing is hypothesized to play a major role in gene diversity in higher organisms. Splice-junction microarrays are microarrays designed to monitor alternative isoforms as opposed to the gene-level measurements common in ordinary gene expression microarrays. Tto deconvolve the microarray measurements, we are proposing a nonlinear interpretable model with parameters corresponding to the isoform fold changes and relative abundances. The model is fit using nonlinear regression. We apply the model to study nonsense mediated degradation in Drosophila melanogaster.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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