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Activity Number:
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78
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Type:
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Invited
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Date/Time:
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Monday, August 4, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #300296 |
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Title:
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Assessing Gene-Environment Interaction in a Genomewide Association Study
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Author(s):
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James Gauderman*+ and Cassandra Murcray and Juan Lewinger and Heather Volk and David Conti and Dalin Li
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Companies:
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University of Southern California and University of Southern California and University of Southern California and University of Southern California and University of Southern California and University of Southern California
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Address:
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1540 Alcazar St, Suite 220, Los Angeles, CA, 90089,
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Keywords:
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interaction ; environment ; association ; gene
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Abstract:
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Genomewide association (GWA) studies are designed to test several hundred thousand single nucleotide polymorphisms (SNPs) for association with a trait. Most testing procedures focus solely on detecting the direct effect of each SNP on the trait. However, for complex human traits, it is commonly believed that gene-environment (GxE) interactions play an important role in etiology. We will review commonly used approaches for detecting GxE interactions. We will also present novel approaches, designed specifically for the GWA context, to efficiently identify genes involved in a GxE interaction. Applications to an ongoing GWA study of asthma and lung function in a large cohort of children will be provided.
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