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Activity Number:
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492
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Type:
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Invited
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Date/Time:
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Thursday, August 7, 2008 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #300184 |
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Title:
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Application of Causal Modeling on Radiation, Inflammation, and Selected Radiation/Inflammation-Induced Health Outcomes
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Author(s):
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Tatsuyuki Kakuma*+ and Yuko Araki and Wan-Ling Hsu and Eiji Nakashima and Kazuo Neriishi and Ritsu Sakata and Norman P. Ross
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Companies:
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Kurume University and Kurume University and The Radiation Effects Research Foundation and The Radiation Effects Research Foundation and Radiation Effects Research Foundation and The Radiation Effects Research Foundation and Radiation Effects Research Foundation
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Address:
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67 Asahi-Mach, Kurume, 830-0011, Japan
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Keywords:
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Low-Grade Inflammation ; Joint Model ; Radiation-Induced Diseases
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Abstract:
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Atomic bomb survivors have persistently increased risk of cancer and non-cancer diseases. The mechanisms of how radiation exposure causes these undesirable health conditions are quite complex. One hypothesis is that radiation exposure results in chronic low-grade inflammation, which in turn may cause elevated risk for some inflammation-related and radiation-induced diseases such as cataract. Inflammation is usually indicated by various biomarkers, and we hypothesized a causal pathway involving radiation, inflammation, inflammation-induced covariates and other risk factors among the atomic bomb survivors in the Adults Health Study. Association among these variables were examined by a joint model where onset of cataract was treated as survival data, latent inflammation, inflammation-induced covariates, and other risk factors including radiation dose were modeled with a structural model.
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