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Activity Number:
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121
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Type:
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Invited
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Date/Time:
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Monday, August 4, 2008 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #300166 |
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Title:
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Adaptive Designs: Why, How, and When?
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Author(s):
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Christopher Jennison*+
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Companies:
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University of Bath
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Address:
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Department of Mathematical Sciences, Bath, International, BA15 1EP, United Kingdom
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Keywords:
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Clinical trials ; Adaptive designs ; Group sequential tests ; Combination tests ; Seamless transition
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Abstract:
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The applications of adaptive design methodology are diverse and one should not expect a simple answer to when it may be beneficial to use such a design. We shall consider a range of application areas and offer conclusions for each. Conventional group sequential tests are relevant to problems of sample size reassessment. However, adaptive designs offer a flexible response to unexpected changes of intent or to rescue an inadequately planned trial. Combination tests at the heart of many adaptive designs play a key role in two-stage studies set up to include treatment selection, change of endpoint, or change of focus to a subpopulation. Combining two of the traditional phases of clinical testing with a "seamless transition" may have benefits of continuity and, ultimately, more rapid recognition of an effective treatment---as long as logistical issues can be addressed.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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