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Activity Number:
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78
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Type:
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Invited
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Date/Time:
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Monday, August 4, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #300146 |
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Title:
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Probability of Detecting Disease-Associated SNPs in Case-Control, Genome-Wide Association Studies
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Author(s):
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Mitchell H. Gail*+ and Ruth Pfeiffer and William Wheeler and David Pee
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Companies:
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National Cancer Institute and National Cancer Institute and Information Management Services and Information Management Services
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Address:
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6120 Executive Blvd., Bethesda, MD, 20892-7244,
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Keywords:
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genetic association study ; genome-wide association study ; detection probability ; single nucleotide polymorphism ; ranking and selection
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Abstract:
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Some case-control genome-wide association studies select promising single nucleotide polymorphisms (SNPs) by ranking corresponding p-values. We define the detection probability (DP) for a specific disease-associated SNP as the probability that the SNP will have one of the T smallest p-values for trend tests of association. The proportion positive (PP) is the fraction of selected SNPs that are true disease-associated SNPs. DP increases with genetic effect size and case-control sample size, and decreases with the number of non-disease-associated SNPs. DP increases very slowly with T. For a genetic odds ratio per minor disease allele of 1.2 or less, even a study with 1000 cases and 1000 controls requires T to be impractically large to achieve an acceptable DP and PP. These ideas are also used to minimize the total cost of a research program that follows up on the selected SNPs.
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