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Activity Number:
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423
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Type:
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Invited
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Date/Time:
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Wednesday, August 6, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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Committee on Women in Statistics
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| Abstract - #300029 |
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Title:
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Nonparametric Linkage Tests Using Affected Pedigree Members: The Work of Alice S. Whittemore
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Author(s):
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Mei-Chiung Shih*+
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Companies:
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Stanford University
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Address:
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HRP Redwood Building, Stanford, CA, 94305,
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Keywords:
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linkage analysis ; allele-sharing methods ; lod scores
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Abstract:
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Nonparametric tests based on allele sharing among pedigree members affected with a given disease are widely used in linkage analysis for gene discovery. In this talk I will review two contributions of Alice S. Whittemore in this area. The first one concerns extending allele sharing methods from affected relative pairs to arbitrary sets of affected pedigree members (Whittemore & Halpern, Biometrics 1994, 50:118--127). The second contribution concerns relating nonparametric allele sharing methods to parametric lod scores tests by a unified likelihood framework (Whittemore, American Journal of Human Genetics 1996, 59:704--716). The impact of this work on the field of statistical genetics will also be discussed.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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