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This is the preliminary program for the 2007 Joint Statistical
Meetings in Salt Lake City, Utah.
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The views expressed here are those of the individual authors and not necessarily those of the ASA or its board, officers, or staff. Back to main JSM 2007 Program page |
= Applied Session,
= Theme Session,
= Presenter| CE_19C | Mon, 7/30/07, 8:30 AM - 5:00 PM | CC-150 D-F |
| Practical Bayesian Clinical Trial Design - Continuing Education - Course | ||
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Section on Bayesian Statistical Science, ASA |
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| Instructor(s): Peter F. Thall, The University of Texas M.D. Anderson Cancer Center | ||
| This short course will cover practical Bayesian methods for clinical trial design and conduct. Attendees should have at least a Masters degree in statistics, or equivalent experience, and an understanding of elementary Bayesian concepts. The course will include numerous illustrations using actual clinical trials. Most examples will be drawn from oncology, although the methods are broadly applicable. Methods for eliciting and calibrating priors, incorporating historical data, and using computer simulation to establish a design's frequentist properties will be illustrated. The morning will be cover phase I and phase I/II designs, including dose-finding using the continual reassessment method and logistic regression models, accommodating multiple ordinal toxicities weighted by their clinical importance, finding optimal dose pairs of two agents used in combination, dose-finding based on efficacy-toxicity trade-offs, optimizing schedule of administration rather than dose, and jointly optimizing dose and schedule. The afternoon will cover single-arm and randomized phase II trials, and hybrid designs that incorporate several methods. These will including a paradigm for monitoring multiple discrete outcomes, phase II designs based on event times, hierarchical Bayesian methods for trials with multiple disease subtypes, using regression to account for patient heterogeneity, adaptive randomization, and optimizing multi-stage dynamic treatment strategies. | ||
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JSM 2007
For information, contact jsm@amstat.org
or phone (888) 231-3473. If you have questions about the Continuing Education program,
please contact the Education Department. |