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Activity Number:
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154
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #310388 |
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Title:
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Testing for Ordered Alternatives in the Analysis of Genetic Association Studies
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Author(s):
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Julia Kozlitina*+
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Companies:
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Southern Methodist University
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Address:
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P.O. Box 750332, Dallas, TX, 75275,
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Keywords:
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genetic ; association ; robust ; order-restricted alternatives
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Abstract:
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Genome-wide association studies hold great potential for helping scientists understand the genetic component of complex human disease. However, the identification of individual variants underlying disease phenotypes remains a challenge for several reasons. Most common variants are likely to have only a minor effect on phenotype, while those alleles that do effect phenotype directly are likely to be found in populations at very low frequencies, so statistical tests will often suffer from low power to detect existing associations. We propose a robust procedure with higher power to detect association, especially when the underlying disease model is unknown.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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