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Activity Number:
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154
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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WNAR
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| Abstract - #310215 |
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Title:
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The Multinode Topological Overlap Measure for Gene Neighborhood Analysis
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Author(s):
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Ai Li*+ and Steve Horvath
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Companies:
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University of California, Los Angeles and University of California, Los Angeles
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Address:
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500 Landfair Ave, Los Angeles, CA, 90024,
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Keywords:
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gene co-expression network ; neighborhood analysis ; toplogiclal overlap measure
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Abstract:
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A pair of nodes in a network is said to have high topological overlap if they are both strongly connected to the same group of nodes. In gene networks, genes with high topological overlap have been found to have an increased chance of being part of the same biological pathway. The use of topological overlap serves as a filter to exclude spurious or isolated connections. A topological overlap measure can be used in network analysis for finding similar nodes or for defining a neighborhood of an initial set of nodes. The standard topological overlap measure allows one to measure pairwise topological overlap in an undirected network. Here we generalize this overlap measure to multiple nodes. The resulting multiTOM measure can be used to define a neighborhood of a initial set of nodes. We provide several applications that show the use of these neighborhoods.
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