JSM Preliminary Online Program
This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 154
Type: Contributed
Date/Time: Monday, July 30, 2007 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #310214
Title: Drug Combination Studies in Preclinical Pharmaceutical Research
Author(s): Joseph Haas*+ and Philip Iversen
Companies: Eli Lilly and Company and Eli Lilly and Company
Address: Lilly Corporate Center, Indianapolis, IN, 46285,
Keywords: drug combination ; synergy ; additivity ; pharmaceutical research ; pre-clinical
Abstract:

Drug combination studies are important in pre-clinical pharmaceutical research. If a combination is synergistic or additive, lower doses can be used to achieve the same or better efficacy with lower toxicity. We compare different definitions of additivity in the bio-medical literature, including Loewe additivity and Bliss independence. We also describe some experimental designs and recent dose-response analysis methods for combination studies. Real data examples will be shown from the fields of oncology and insomnia.

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Revised September, 2007