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Activity Number:
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154
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #310081 |
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Title:
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A Novel Application of Quantile Regression for Identification of Cartilage Biomarkers in Equine Microarray Data
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Author(s):
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Liping Huang*+ and Christopher Saunders and Wenying Zhu and Jamie MacLeod and Arnold Stromberg and Arne Bathke
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Companies:
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University of Kentucky and George Mason University and University of Kentucky and University of Kentucky and University of Kentucky and University of Kentucky
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Address:
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, Lexington, KY, ,
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Keywords:
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quantile regression ; microarray data
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Abstract:
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Total RNA from equine articular cartilage and 10 other tissues was isolated. Two color array experiments were performed to compare the gene expression profile of cartilage versus each of the other 10 tissues. Cartilage-specificity of expression was determined using quantile regression analysis by estimating conditional quantiles of the log2 ratios given the observed average log2 intensities. Nine conditional quantiles were estimated. For each observed gene intensity in a given tissue comparison, a cartilage-specificity score was generated by substituting the Z-score for the corresponding estimated regression quantile. Thirty-eight probe sets were identified that exhibit expression above the 95th conditional quantile in all 10 of the cartilage/tissue comparisons analyzed. The list includes established biomarkers of articular cartilage.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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