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Activity Number:
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154
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #309350 |
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Title:
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Effect of Ignoring Baseline on Transitions from Intact Cognition to Dementia
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Author(s):
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Richard J. Kryscio*+ and Lei Yu and David Snowdon and Suzanne Tyas
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Companies:
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University of Kentucky and University of Kentucky and University of Waterloo
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Address:
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, Lexington, KY, 40505,
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Keywords:
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dementia ; mild cognitive impairment ; Markov chain ; baseline ; random effect ; polytomous logistic
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Abstract:
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We investigate bias introduced by ignoring baseline on transitions from intact cognition to dementia with mild cognitive impairment and global impairments as intervening states. Transitions among states are modeled by a Markov chain (MC) with transition probabilities depending on a single covariate. Two cases are examined by simulation (i) a true MC is left truncated and (ii) cognitive decline is assumed to be a linear model or a double change point model with random slopes. Results are illustrated with an application from the Nun Study, a longitudinal cohort of 678 participants 75+ years of age at baseline.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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