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Activity Number:
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380
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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ENAR
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| Abstract - #310343 |
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Title:
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Gene-Environment Interaction Test for Dichotomous Traits in Nuclear Families
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Author(s):
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Thomas Hoffmann*+ and Nan Laird
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Companies:
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Harvard University and Harvard University
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Address:
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655 Huntington Ave, Boston, MA, 02115,
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Keywords:
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Gene environment interaction ; Genetics ; Sib pairs
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Abstract:
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We first propose an extension of the Lake and Laird permutation test for trios to sibpairs, and develop an alternative empirical variance. Extending to discordant sibs leads to an invalid test statistic, but sibpairs with at least one affected is valid. We explore the degree of bias in this test to determine when it will be negligible. Then, due to limitations in the test, we explore the use of the Vansteelandt and Lange gene-environment interaction test on dichotomous traits. We compare these results to other gene-environment interaction tests in trios or sibpairs.
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