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Activity Number:
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134
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Type:
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Topic Contributed
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #310256 |
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Title:
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Overcoming Practical, Statistical, and Robotic Challenges in Bioassay
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Author(s):
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David Lansky*+
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Companies:
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Precision Bioassay
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Address:
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257 S Union St, Burlington, VT, 05401,
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Keywords:
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Abstract:
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Good animal husbandry, statistical design, and analysis are all needed for a successful bioassay. Identifying experimental units is challenging for properly randomized assays; for the all-too-common non-randomized assay the challenges grow. Practical constraints in the laboratory often create multiple levels of blocking, serial dilution error, and design structures more complex than split-units. Relative potency is a non-linear function of the observed nonlinear response and there is often non-additivity in the variation of the response. With non-constant variance, outliers, and insufficient access to statisticians familiar with bioassay there are many opportunities for ad-hoc "solutions." By combining good designs, statistical software to drive laboratory robots, and mixed model analyses we aim to provide a comprehensive solution that facilitates doing bioassay well.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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