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Activity Number:
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51
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Type:
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Topic Contributed
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Date/Time:
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Sunday, July 29, 2007 : 4:00 PM to 5:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #310068 |
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Title:
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Minority Differences in Cancer Survival on Cooperative Group Clinical Trials
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Author(s):
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Beow Yong Yeap*+ and Marvin Zelen
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Companies:
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Massachusetts General Hospital/Harvard Medical School and Harvard School of Public Health
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Address:
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50 Staniford St, Boston, MA, 02114,
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Keywords:
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African-American ; Cancer clinical trials ; Survival ; matching
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Abstract:
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Outcome comparisons between racial groups generally lack the individual data to adjust for patient variation in disease, therapy and institution factors. The Eastern Cooperative Oncology Group (ECOG) has conducted multi-center clinical trials in adult cancers nationwide since 1955. We use the ECOG database to determine the outcome of African-American (AA) patients on therapeutic protocols during 1976-2005. To minimize patient variation without explicit covariate modeling, each AA proband was matched by gender to a White patient enrolled on the same protocol, assigned to the same arm and treated at the same hospital. We previously found AA patients experienced a higher death rate, with the deficit distributed disproportionately among AA women. Using a larger sample size and extended follow-up, we examine whether the excess mortality of AA patients has diminished on ECOG clinical trials.
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