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Activity Number:
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291
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics and the Environment
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| Abstract - #309957 |
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Title:
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Exploring the Relation Between Frailty and Negative Health Outcomes Associated with Air Pollution in an Older Population
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Author(s):
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Sandrah Eckel*+ and Thomas A. Louis and Karen Bandeen-Roche and Linda Fried and Helene Margolis
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Companies:
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Johns Hopkins Bloomberg School of Public Health and Johns Hopkins University and Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Medical Institutions and California Department of Health Services
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Address:
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Department of Biostatistics, Baltimore, MD, 21205,
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Keywords:
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effect modification ; frailty models ; longitudinal models
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Abstract:
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In relating air pollution exposure to health effects in older adults, age is a noisy surrogate of health status. In gerontology, an individual is frail if reduced to a vulnerable state and at risk for increased disability or disease. Our goal is to implement models using the frailty concept in place of age. We develop, evaluate and apply statistical methodology for longitudinally analyzing the health effects of an exposure (air pollution) while taking into account the heterogeneity of individual level health status, both across time and between individuals. We use data from the Cardiovascular Health Study (CHS) and the Environmental Factors Ancillary Study to CHS. Statistical challenges include representing frailty in our model, developing appropriate predictor summaries and choosing appropriate longitudinal and survival model frameworks.
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