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Activity Number:
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415
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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WNAR
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| Abstract - #309757 |
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Title:
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Two-Way Hierarchical Phylogenetic Models: An Application to HIV-1 Evolution During Fusion Inhibitor Therapy
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Author(s):
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Christina Ramirez Kitchen*+ and Marc A. Suchard
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Companies:
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University of California, Los Angeles and University of California, Los Angeles
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Address:
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650 Charles E Young Dr, Los Angeles, CA, 90095-1772,
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Keywords:
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Bayesian ; phylogenetic ; heirarchical ; HIV ; T20 ; genetics
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Abstract:
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We studied intra-host viral evolution during T20 treatment during advanced HIV disease. We examined clones from 9 patients with incomplete viral suppression on T20, and who interrupted T20 while remaining on background antiretrovirals. Clones were sequenced from gp41 and gp120 at three time points: pre-T20, post-T20 failure and post-T20 interruption. To test the hypothesis of dominant selective pressure simultaneously in gp41 and gp120 across patients, we extended the Bayesian hierarchical phylogenetic model to a two-way ANOVA design. The first dimension is across patients and the second is across gene regions. The hierarchical prior on patient trees can be thought of as a two-way contingency table with each cell having multinomial probabilities under a log linear formulation. This model can also be used for Bayesian outlier detection.
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