|
Activity Number:
|
66
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Sunday, July 29, 2007 : 4:00 PM to 5:50 PM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #309650 |
|
Title:
|
EWOC Online: An Interactive Web Tool for Dose Escalation in Cancer Phase I Clinical Trials
|
|
Author(s):
|
Zhiheng Xu*+ and Haibin Wang and Mourad Tighiouart and André Rogatko
|
|
Companies:
|
Emory University and Emory University and Emory University and Emory University
|
|
Address:
|
1365B Clifton Rd, Atlanta, GA, 30322,
|
|
Keywords:
|
EWOC ; Maximum tolerated dose ; Bayesian methods ; Cancer phase I clinical trial
|
|
Abstract:
|
EWOC (escalation with overdose control) online is a web-based program which uses Bayesian methods in dose escalation schemes to assign dose levels sequentially to patients in cancer phase I clinical trials. It has a detailed tutorial which guides users in designing phase I trial with the goal of approaching maximum tolerated dose as fast as possible while controlling the probability of overdosing patients. Table for sequential dosages and plot for tree of doses can be generated from the program. The dose assignment can be recalculated by modifying the input parameters. Simulation module will also be available for users to simulate a real phase I trial for a certain number of cancer patients. Operating characteristics such as consistency and safety of the trial using this methodology have been well established. EWOC online can be accessed at http://sisyphus.emory.edu:8080/ewoc/ewoc3.htm.
|
