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Activity Number:
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379
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309604 |
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Title:
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Permuted Block Randomization and Balance in Clinical Trials
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Author(s):
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John (Joong Hee) Han*+ and Lee-Lian Kim
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Companies:
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Centocor, Inc. and Centocor, Inc.
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Address:
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200 Great Valley Parkway, Malvern, PA, 19355,
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Keywords:
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block randomization ; balance ; clinical trial
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Abstract:
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There are different methods to randomly allocate subjects to treatment arms in a clinical trial. One method that is commonly used is permuted block randomization. The major advantage of permuted block randomization is that when all blocks are completed at the end of a clinical trial, there is complete balance between treatment groups. This is true for the whole trial as well as for any stratification factor that may have been incorporated into the randomization scheme. However, if there are few subjects in stratification cells, incomplete blocks could exist, which may lead to imbalance among treatment groups. This presentation will explore the degree of imbalance that may arise and if this imbalance can affect the results of a trial.
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