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Activity Number:
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534
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 2, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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IMS
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| Abstract - #309345 |
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Title:
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Using Point Process Models To Describe Oscillatory Spiking in the Subthalamic Nucleus of Parkinson's Patients
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Author(s):
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Uri Eden+ and Emery N. Brown and Emad Eskandar and Sridevi V. Sarma*+
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Companies:
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Boston University and Massachusetts General Hospital and Massachusetts General Hospital and Massachusetts Institute of Technology
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Address:
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111 Cummington St, Boston, MA, 02215, 54 Myrtle Street, Unit 2, Somerville, MA, 02145,
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Keywords:
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Neural Data ; Point Processes ; GLM
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Abstract:
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Abnormal oscillatory firing patterns of neurons in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) have been postulated to play a role in the pathogenesis of motor deficits. We characterized the firing properties of these neurons by constructing GLM point process intensity models using spline basis functions that relate the spiking of each neuron to movement variables and the neuron's past firing history, both at short and long time scales. By calculating maximum likelihood estimators for all of the parameters and their significance levels, we were able to describe the relative propensity of aberrant STN spiking in terms of factors associated with reaching movements, with intrinsic properties of the neurons, and factors that may be related to disregulated network dynamics and to determine their relative importance in describing the observed data.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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