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Activity Number: 369
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #309273
Title: Crossover Designs Based on Type I Orthogonal Arrays for a Self and Simple Mixed Carryover Effects Model with Correlated Errors
Author(s): Samad Hedayat*+ and Zhiwu Yan
Companies: University of Illinois at Chicago and University of Illinois at Chicago
Address: Dept of Math Stat Compt Sci, Chicago, IL, 60607-7045,
Keywords: crossover designs ; self carryover effects ; simple mixed carryover effects ; universal optimality ; type I orthogonal arrays
Abstract:

We investigate the performance of crossover designs based on type I orthogonal arrays for a self and simple mixed carryover effects model in the presence of correlated errors. Assuming that the between-subject errors are independent while the within-subject errors behave according to the stationary first-order autoregressive and moving average processes, analytical optimality results for 3-period designs are establish and, as an illustration, numerical details for a number of 4-period cases are tabulated.

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Revised September, 2007