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Activity Number:
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530
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 2, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309239 |
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Title:
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Propensity Score--Adjusted Survival Analysis
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Author(s):
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Nathan Carter*+ and Ed McMullen and Jennifer Mischke
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Companies:
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Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
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Address:
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1400 Hamline Avenue, St. Paul, MN, 55112,
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Keywords:
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Propensity Scores ; Survival Analysis ; Historical Control ; Simulation
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Abstract:
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Propensity score analysis allows adjustment for differences in baseline characteristics between two study populations. This analysis is commonly used in single arm clinical trials with a historical control. An example of this would be a stent trial, which compares the performance of a new stent to a historical control of an FDA previously approved stent. This presentation will examine the effect that propensity score adjustment has on the survival analysis conducted for a historical control stent trial. Additionally, simulations will be done to examine the possible effects propensity adjustment could have on survival analysis.
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