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Activity Number:
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245
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #308881 |
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Title:
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Constructing Gene Association Network for Rheumatoid Arthritis Using the Backward Genotype-Trait Association (BGTA) Algorithm
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Author(s):
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Yuejing Ding*+ and Tian Zheng and Iuliana Ionita-Laza and Lei Cong and Shaw-Hwa Lo
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Companies:
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Columbia University and Columbia University and Harvard University and Columbia University and Columbia University
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Address:
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1255 Amsterdam Ave, New York, NY, 10027,
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Keywords:
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BGTA ; GTD score ; Gene-gene interaction ; Gene Association Network
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Abstract:
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In this paper, we propose a two-stage analysis of whole-genome scan data using the BGTA algorithm, and also demonstrate how to construct gene association network based on the results from the BGTA algorithm. We will illustrate this method using a genome scan SNP dataset ascertained by North American Rheumatoid Arthritis Consortium (NARAC). This method is able to capture both the marginal and interaction effects of multiple susceptibility loci. This novel gene association network provides, for the first time in the literature, the possible interaction between markers/genes which may be useful for the biological interpretation.
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