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Activity Number:
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187
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Type:
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Topic Contributed
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Date/Time:
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Monday, July 30, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #308859 |
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Title:
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Fence Methods for Quantitative Trait Loci Mapping in Humans
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Author(s):
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Thuan Nguyen*+ and Jiming Jiang and Jie Peng
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Companies:
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University of California, Davis and University of California, Davis and University of California, Davis
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Address:
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2900 Solano Park Circle Apt 2623, Davis, CA, 95616,
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Keywords:
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Fence method ; Identity by descent (IBD) ; Model selection ; Pedigree data ; QTL mapping ; Variance component
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Abstract:
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The goal of quantitative trait loci (QTL) mapping is to identify chromosomal regions that affect particular quantitative traits. In humans, pedigree data is collected to detect the cosegregation of phenotypes and the shared genetic material between relatives. In QTL mapping, variance components arising from the trait genes, polygenic and environmental effects are often used to model the covariance structure of the phenotypes given the IBD sharing matrix. The genetic control of a quantitative trait is widely thought to involve a number of loci. However, standard genome scanning methods usually ignore these possibilities, presumably because they involve more complex models partially due to the large number of putative trait loci. Thus, a model selection approach seems useful in such a context. We explore a recently developed model selection strategy, called fence method, in QTL mapping.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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