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Activity Number:
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470
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308602 |
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Title:
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Test Homogeneity of Risk Difference Across Subgroups in Clinical Trials
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Author(s):
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Lanju Zhang*+ and Harry Yang
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Companies:
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MedImmune, Inc. and MedImmune, Inc.
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Address:
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One Medimmune Way, Gaithersburg, MD, 20878,
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Keywords:
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score test interval
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Abstract:
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A new method on test of homogeneity of risk difference across different groups in clinical trials is proposed. This method is a combination of interval estimation of risk difference based on score test and traditional weighted least squares statistics. The type I error rate of the new method should be robust against the relative small sample size. The performance of the new method will be simulated and compared to the traditional method.
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