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Activity Number:
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66
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Type:
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Contributed
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Date/Time:
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Sunday, July 29, 2007 : 4:00 PM to 5:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308502 |
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Title:
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Elicitation of Expert Opinion and Bayesian Fitting of a Logistic Dose-Response Curve
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Author(s):
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Les Huson*+ and Nelson Kinnersley
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Companies:
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GNB Limited and Roche Products Limited
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Address:
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Chislehurst Business Centre, Chislehurst, BR7 6LH, United Kingdom
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Keywords:
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bayesian ; logistic ; dose-response ; elicitation ; prior
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Abstract:
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Before undertaking a Phase I study in which a dose-response relationship was to be investigated, we elicited prior opinion about the relationship from a group of internal experts, using a graphical technique. We describe this elicitation process, and also discuss two methods which we used to convert the expert opinion into prior distributions for the parameters of a logistic dose-response curve. The first such technique combines the CDF approach with a simulation step, and the second involves forming priors by bootstrapping. We also report the results from Bayesian analyses combining these priors with data from the Phase I study.
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