|
Abstract:
|
Advances in experimental technology have made possible hypothesis-free, genome-wide, case-control association studies. These are proving to be a very powerful tool for unlocking the genetic basis of common human diseases, but they bring with them a number of challenging statistical problems and opportunities. The talk will describe some of these in the context of the largest such study to date, the Wellcome Trust Case Control Consortium, a UK collaboration studying the genetic basis of seven common human diseases which measured the genetic types of 2000 cases for each disease and 3000 common controls at each of 500,000 positions in the human genome. The study identified more than 10 novel genes involved in the etiology of the diseases studied.
|
