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Abstract:
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A large number of epidemiologic studies of persons exposed to radiation for environmental, medical, and occupational reasons have been conducted. In many of these studies, including the important study of Japanese A-bomb survivors, well characterized dose estimates are available for individual subjects. This wealth of data has led to sophisticated statistical models for the excess relative and absolute risk. These models serve as the basis for estimating lifetime risks from low level exposures that occur in environmental, diagnostic medical, and occupational settings of interest Issues to be discussed include combining data from several relevant studies, extrapolating from high to low doses and dose rates, modification of risk by factors such as age and gender, and transporting risks developed from specific study populations to other populations with different baseline rates.
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