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Activity Number:
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343
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics and the Environment
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| Abstract - #310359 |
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Title:
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The Power of Linkage Analysis of a Quantitative Disease Endophenotype
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Author(s):
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Zhuying Huang*+ and Nancy Mendell
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Companies:
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Stony Brook University and State University of New York at Stony Brook
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Address:
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69 Eastwood Blvd, Centereach, NY, 11720,
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Keywords:
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quantitative trait ; power of linkage ; pleiotropy ; simulation
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Abstract:
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The power of linkage analysis has been widely studied for simple mendelian diseases. In this report, we consider a complex disease. We assume there is a pleiotropic quantitative trait locus that also affects disease risk. The sample of sib pairs being used consists of a disease-affected proband and plus a random chosen sibling. The linkage analysis is performed on the quantitative trait. We present the results of a power study of this design done through simulation. We consider the cases where theta equals 0.05 and the quantitative trait has high heritability and penetrance values range from 0.01 t0 0.5.
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