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Activity Number:
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416
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #310160 |
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Title:
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Gene-Gene and Gene-Environment Interactions for Complex Traits
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Author(s):
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Qinyi Cheng*+ and Mengling Liu and Yongzhao Shao
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Companies:
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New York University and New York University and New York University
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Address:
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650 1st Ave Rm 581, New York, NY, 10016,
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Keywords:
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gene-gene interaction ; gene-environment interaction ; association study ; Ancestry informative marker
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Abstract:
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In studies of gene-gene and gene-environment interactions for complex traits, latent population stratification usually entails complications. Unobserved differences in subpopulation proportions among cases and controls may lead to false positive results. To incorporate potential latent population substructure into the analysis, we propose a joint model of phenotypic traits and genotypic information under the presence of genetic information of Ancestry-Informative-Markers (AIMs). Moreover, numerical algorithms to carry out the estimation of relevant parameters are developed. Simulation studies are used to demonstrate the effect of taking consideration of population admixture.
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