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Activity Number: 376
Type: Contributed
Date/Time: Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #310054
Title: Regional Spatial Cluster Detection for Repeated Measured Outcomes
Author(s): Andrea Cook*+ and Diane R. Gold and Yi Li
Companies: Group Health Center for Health Studies and Channing Laboratory, Brigham and Women's Hospital, and Harvard Medical School and Harvard School of Public Health
Address: 1730 Minor Avenue Suite 1600, Seattle, WA, 98101,
Keywords: Cluster Detection ; Cumulative Residuals ; Repeated Measures ; Spatial ; Wheeze
Abstract:

Spatial cluster detection has become an important methodology in quantifying the effect of hazardous exposures. Previous methods have focused on outcomes that are binary or continuous. However, there are no spatial cluster detection methods proposed for repeated measured outcomes. This paper proposes a method using cumulative geographic residuals through a permutation test for repeated measured outcomes. A major advantage of this method is its ability to readily incorporate information on study participants relocation, which most cluster detection statistics cannot. Application of these methods will be illustrated by the Home Allergens and Asthma prospective cohort study analyzing the relationship between environmental exposures and repeated measured outcome, persistent wheezing in the last six months, while taking into account moving.


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Revised September, 2007