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Activity Number:
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530
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 2, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309980 |
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Title:
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Assessment of Goodness-of-Fit of Cox Model with Multiple Predictors in Drug Eluting Stent Trial Efficacy Evaluation
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Author(s):
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Frank Zhou and Yukiko Imai and Hong Wang*+
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Companies:
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Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
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Address:
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100 Boston Scientific Way, Marlborough, MA, 01752,
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Keywords:
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COX Model ; Goodness-of-fit ; Residuals ; Drug-Eluting Stent
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Abstract:
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In this paper, we examined goodness-of-fit of Cox regression model assessing co-morbidities, cardiac risk factor, and lesion characteristics at baseline and post-procedure as predictors for the clinical outcome of target lesion revascularization (TLR) in the randomized trials of drug eluting stent. The predictors of TLR based on fitted main effect Cox model were evaluated for their goodness-of-fit based on standard error, 95% confidence interval, p-value and residual from each parameter. The Cook's distance statistic plots are used to demonstrate the effect on TLR by each particular subject. The overall goodness-of-fit tests based on grouping quartiles of risk have been applied to the model for its interpretation. Inference on treatment effect before and after the goodness-of-fit assessment were compared.
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