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Activity Number:
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470
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309521 |
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Title:
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Reporting Quality-of-Life Results Using Percent Change from Baseline Analysis
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Author(s):
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Jen-Fue Maa*+ and Kao-Tai Tsai and Daniel Seekins and Rozina Khanna
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Companies:
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Bristol-Myers Squibb Company and Bristol-Myers Squibb Company and Bristol-Myers Squibb Company and Bristol-Myers Squibb Company
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Address:
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1 Colonial Ct, Plainsboro, NJ, 08536,
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Keywords:
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FAHI ; HIV/AIDS ; patient reported outcome
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Abstract:
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It is often a challenge to interpret if a change in quality of life (QoL) scores is clinically significant since different measures may produce different results. A recent HIV trial demonstrated significant improvements in CD4 cell count and QoL using a psychometric instrument (FAHI) in virally suppressed patients switching HIV medications. Both percent change and absolute change from baseline in physical function of QoL were correlated with improvement in CD4 cell count (r=0.21 p=0.001 and r=0.18 p=0.004 respectively) with higher correlation observed in the percent change analysis. Absolute change does not show a definitive mathematical advantage over percent change and vice versa for correlation to clinical outcomes. Changes in absolute numbers may not be easy to interpret for most clinicians. We propose to interpret the finding by percent improvement in QoL.
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