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Activity Number:
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415
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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WNAR
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| Abstract - #309394 |
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Title:
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A Multiscale Model of HIV Dynamics Linking In-Host Processes with Virus Spread in Human Populations
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Author(s):
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Lilit Yeghiazarian*+ and William G. Cumberland and Otto Yang
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Companies:
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University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles
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Address:
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Department of Biostatistics, Los Angeles, CA, 90025,
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Keywords:
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multi-scale ; sexual networks ; model ; in-host process
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Abstract:
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Interactions of HIV with the immune system have been studied experimentally and using mathematical models. Epidemiological studies provided insight into HIV dynamics in human populations. The importance of social network topology in epidemics became apparent as research on structure of technological networks progressed. We have developed a mathematical model that bridges the scales between in-host processes and HIV transmission in human sexual networks. Each individual goes through a sequence of health states reflecting HIV status and treatment. Associated with each state is an in-host model of HIV-immune system interactions. At the same time, each individual is a node in a sexual network. We investigate the effect of a variety of medical care criteria and decisions on both the health state of the individual, and on the spread of disease in populations with different network topologies.
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