JSM Preliminary Online Program
This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.


Back to main JSM 2007 Program page

Activity Number: 458
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #309316
Title: Bayesian NonInferiority Trial Design Using Hierarchical Models
Author(s): Yongyi Yu*+ and Frank Zhou and Scott Wehrenberg and Ming-Hui Chen
Companies: Boston Scientific Corporation. and Boston Scientific Corporation and Boston Scientific Corporation and University of Connecticut
Address: 1 Scimed Pl, Maple Grove, MN, 55311,
Keywords: Drug-eluting stent ; Hierarchical model ; Simulation ; MCMC ; Operating Characteristics
Abstract:

A Bayesian trial is proposed to determine if the new generation drug-eluting stents (DES) is non-inferior to the first generation drug-eluting stents. A hierarchical model is used to incorporate historical information available on first generation DES trials. Study success criteria are based on posterior probability of non-inferiority. Sample sizes, borrowing strategy, and corresponding operating characteristics are simulated and compared to frequentist approach.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2007 program

JSM 2007 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised September, 2007