JSM Preliminary Online Program
This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 537
Type: Contributed
Date/Time: Thursday, August 2, 2007 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #309289
Title: A Model-Based Assessment of Antitumor Activity for Solid Tumor Xenograft Studies
Author(s): Jianrong Wu*+
Companies: St. Jude Children's Research Hospital
Address: 332 N Lauderdale St, Memphis, TN, 38016,
Keywords: Antitumor activity ; Exponential growth model ; Tumor growth delay ; Xenograft model
Abstract:

Three exponential tumor growth models are developed to characterize tumor growth in the mouse solid tumor xenograft studies for the Pediatric Preclinical Testing Program (PPTP) (Houghton, et. al, 2006). Furthermore, a model-based antitumor activity measurement, the AUC ratio, is proposed. The typical antitumor activity measurements used in preclinical xenograft studies, such as $\log_{10}$ cell kill and tumor growth inhibition T/C could either be inapplicable or mislead the antitumor activity evaluation. The AUC ratio provides a more insightful antitumor activity evaluation throughout the entire treatment period.

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Revised September, 2007