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Activity Number:
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245
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #309077 |
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Title:
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Complex Demodulation Applied to bZIP and bHLH-PAS Protein Domains
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Author(s):
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Charles Smith*+ and Zhi Wang and William R. Atchley
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Companies:
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North Carolina State University and North Carolina State University and North Carolina State University
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Address:
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Department of Statistics, Raleigh, NC, 27695-8203,
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Keywords:
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periodicity ; entropy ; functional region
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Abstract:
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Proteins are built with molecular modular building blocks such as an alpha-helix, beta-sheet, loop region and other structures. This is an economical way of constructing complex molecules. Periodicity analysis of protein sequences has allowed us to obtain meaningful information concerning their structure, function and evolution. Here complex demodulation (CDM) is introduced to detect functional regions in protein sequence data. More specifically, we analyzed bZIP and bHLH-PAS protein domains. Complex demodulation provided insightful information about changing amplitudes of periodic components in protein sequences. It was found that the local amplitude minimum or maximum of the 3.6-aa periodic component is associated with protein structural or functional information since the extrema are mainly located in the boundary area of two structural or functional regions.
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