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Activity Number:
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233
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #308896 |
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Title:
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Biodosimetry in the A-Bomb Survivors' Cohort
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Author(s):
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Daniel Stram*+
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Companies:
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University of Southern California
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Address:
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1540 Alcazar Street, Lost Angeles, CA, 91001,
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Keywords:
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Radiation ; Measurement Errors ; Instrumental Variables
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Abstract:
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The follow-up of the A-bomb survivors is a primary source of information concerning the human health effects of exposure to radiation. Quantification of risk is based upon a physical dosimetry system that estimates dose without reference to any biological endpoints. There are a large number of survivors for whom data on one or more of the following endpoints exists: (1) acute radiation symptoms immediately following exposure; (2) chromosome aberrations and mutational analysis for the GPA locus; (3) occurrence of radiation induced cataracts and; (4) ESR-based dose measurements of tooth enamel. We describe the use of these biological dosimetry data in order to estimate and give confidence intervals for parameters in the dosimetry error model. We also outline a proposal to develop a "Biologically enhanced" dosimetry system for primary risk estimation for the follow-up study.
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