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Activity Number:
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548
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Type:
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Contributed
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Date/Time:
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Thursday, August 2, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #308791 |
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Title:
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Extension of the Cohort Analysis for Genetic Epidemiology Program To Assess Excess Risk of Cancer
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Author(s):
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Mei Liu*+ and Carol J. Etzel+ and Michael Scheurer and Melissa Bondy and Sara Strom and Christopher I. Amos
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Companies:
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The University of Texas M.D. Anderson Cancer Center and The University of Texas M.D. Anderson Cancer Center and The University of Texas M.D. Anderson Cancer Center and The University of Texas M.D. Anderson Cancer Center and The University of Texas M.D. Anderson Cancer Center and The University of Texas M.D. Anderson Cancer Center
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Address:
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1155 Pressler Street, Houston, TX, 77030, 1155 Pressler Street, Houston, TX, 77030,
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Keywords:
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Glioma ; Familial aggregation of cancer ; Incidence ; SEER ; Standard Incidence Ratio
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Abstract:
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Cohort Analysis for Genetic Epidemiology (CAGE) is a program that calculates standardized cancer incidence ratios assuming the observed number of malignancies follow a Poisson distribution. The original database was the Connecticut Tumor Registry (CTR) (1935--1985), the oldest in the Surveillance, Epidemiology, and End Results (SEER) program. We updated the database to include CTR rates through 1995 and created a second database for all SEER data (1975--2000). The SEER Hispanic data was limited to 1991--2000, thus we imputed rates based on incidence rates for Whites. We applied our updated program to assess excess of cancer in relatives of 1648 glioma patients. We found significant excess of cancer among relatives of Whites and Blacks, but not for Hispanics, suggesting our imputation did not result in erroneous excess of cancer.
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