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Activity Number:
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327
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Nonparametric Statistics
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| Abstract - #308532 |
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Title:
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Two-Stage Tests for Association on the X Chromosome
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Author(s):
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Jungnam Joo*+
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Companies:
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National Heart, Lung, and Blood Institute
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Address:
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NIH, 6707 Democracy Blvd, Bethesda, MD, 20892-5478,
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Keywords:
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association ; Two-stage test ; Genome-wide association study ; significance level
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Abstract:
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Testing association for markers on the X chromosome possesses a unique feature due to the fact that males carry only one copy of X chromosome. Compared to the extensive research that has been done for markers on the autosomal chromosomes, few work has been done for markers on the X chromosome. In my talk at the last JSM, I presented several combinations of two test statistics based on male and female samples separately. In this talk, I will present several two-stage tests where males are used in the first stage and females are used in the second stage. The choices of significance levels for the two stages are discussed. Simulation studies are conducted to examine the properties of the proposed method, and the results are applied to data from a genome-wide association study for age-related macular degeneration (AMD).
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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