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Activity Number:
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100
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Type:
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Topic Contributed
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Date/Time:
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Monday, July 30, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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WNAR
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| Abstract - #308462 |
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Title:
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Statistical Methods for Differential Diagnosis of Second Primary Cancers from Metastases
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Author(s):
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Colin B. Begg*+
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Companies:
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Memorial Sloan-Kettering Cancer Center
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Address:
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307 East 63rd St, 3rd Floor, New York, NY, 10021,
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Keywords:
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metastases ; statistical ; clonal ; cancer ; differential ; tumors
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Abstract:
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In recent years numerous investigators have conducted studies of pairs of tumor specimens from the same patient to determine whether the tumors share a clonal origin. These studies can be of considerable clinical significance, especially in settings where the distinction of a new primary cancer and metastatic spread of a previous cancer would lead to radically different indications for treatment. Studies of clonality have typically involved comparison of the patterns of somatic mutations in the tumors at candidate genetic loci to see if the patterns are sufficiently similar to indicate a clonal origin. More recently, some investigators have explored the use of array CGH for this purpose. In this talk new statistical approaches to this problem will be presented that are suited to each of these types of data, along with the results of studies to examine the validity of the methods.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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