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Activity Number:
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11
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Type:
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Invited
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Date/Time:
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Sunday, July 29, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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ASA, Utah Chapter
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| Abstract - #307990 |
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Title:
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Cognitive Change as a Biomarker in the Early Detection of Alzheimer's Disease
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Author(s):
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Gordon J. Chelune*+
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Companies:
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The University of Utah
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Address:
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Center for Alzheimer's Care, Imaging and Research, Salt Lake City, UT, 84108,
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Keywords:
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Reliable Change Methods ; Individual Trajectories ; Dementia ; Cognitive Assessment of Change ; norms for change
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Abstract:
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Alzheimer's Disease (AD) is characterized by progressive cognitive impairment. For new drug therapies to be maximally effective, early detection is critical. Single-point assessments using cohort norms are often insensitive early in the disease course as subtle neurocognitive changes may be masked by the effects of normal aging. Increasingly, there is reliance on serial testing to identify abnormal cognitive trajectories. However, norms for cognitive change do not exist, and there is a paucity of objective methods to characterize patterns of reliable change at the level of the individual. Regression-based reliable change methods may provide a means for identifying abnormal cognitive trajectories across serial assessments early in the disease course, even when the individual is still considered to be within the normal range, thus providing a potentially useful biomarker of prodromal AD.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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