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Activity Number:
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172
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Type:
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Invited
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Date/Time:
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Monday, July 30, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307888 |
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Title:
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Sample Size Estimation for Omics Experiments
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Author(s):
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Gregory R. Warnes*+ and Peng Liu
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Companies:
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University of Rochester and Iowa State University
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Address:
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601 Elmwood Dr, Box 630, Rochester , NY, 14534,
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Keywords:
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sample size ; microarray ; omics ; experimental design ; proteomics ; software
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Abstract:
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"Omics" technology is widely applied in biomedical and pharmaceutical research. The huge number of individual measurements for each sample make it difficult to apply traditional sample size calculation techniques and has left most practitioners to rely on rule-of-thumb techniques. In this paper, we describe and demonstrate a simple method for performing and visualizing sample size calculations for ``omics'' experiments. We then summarize simulation results showing that this method performs well, even under a variety of departures from our simplifying assumptions, provided that the underlying formula for computing sample size has been appropriately selected. Although we demonstrate sample size calculation only for the two-sample pooled t-test, it is trivial to substitute an alternative sample size formula appropriate to the problem at hand.
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