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Activity Number:
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120
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Type:
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Invited
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #307738 |
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Title:
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A Method for the Detection of Alternative Splicing from Exon Array Data
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Author(s):
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Terence Speed*+
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Companies:
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University of California, Berkeley
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Address:
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367 Evans Hall, #3860, Berkeley, CA, 94720,
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Keywords:
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exon microarrays ; alternative splicing
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Abstract:
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Analyses of EST data show that alternative splicing is much more widespread than once thought. The advent of exon and tiling microarrays means that researchers now have the capacity to experimentally measure alternative splicing on a genome-wide scale. New methods are needed to analyze the data from these arrays. We present a method, FIRMA (Finding Isoforms using Robust Multichip Analysis), for detecting alternative splicing in exon array data. FIRMA has been developed for Affymetrix exon arrays, but could in principle be extended to other exon arrays, or to tiling array data. We have evaluated the method using simulated data, and have also applied it to a considerable body of data from human tissues, including tumors. Some of the successes and failures of our approach will be described in the talk.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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