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Activity Number:
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491
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Type:
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Invited
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Date/Time:
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Thursday, August 2, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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IMS
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| Abstract - #307708 |
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Title:
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A Simple and Improved Correction for Population Stratification in Genetic Association Studies
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Author(s):
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Michael Epstein*+
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Companies:
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Emory University
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Address:
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School of Medicine, Atlanta, GA, 30322,
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Keywords:
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Abstract:
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Case-control studies of disease-gene association must often correct for potential bias resulting from the effects of population stratification, which originates from the coupling of allele-frequency heterogeneity to disease-risk heterogeneity within a population. Such stratification remains an important issue in association studies, even within populations thought to be homogeneous in nature. To provide an improved correction for stratification, we propose a simple two-step procedure. First, we construct a model for the odds of disease given a set of marker loci (excluding the loci of interest) that can provide information on population substructure. We use the first-step model to assign subjects to strata based on their odds of disease given marker genotypes. Then, in the second step, we test for disease-gene association adjusting for the strata using logistic regression.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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