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Activity Number:
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144
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Type:
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Contributed
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Date/Time:
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Monday, August 7, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #307272 |
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Title:
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Estimating the Causal Effect of LTVV on ALI with G-Computation
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Author(s):
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Weiwei Wang*+ and Daniel Scharfstein and Dale Needham and Roy Brower and Peter Pronovost
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Companies:
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Johns Hopkins University and Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Medical Institutions and Johns Hopkins Medical Institutions and Johns Hopkins Medical Institutions
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Address:
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615 N. Wolfe Street, Baltimore, MD, 21205,
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Keywords:
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causal inference ; g-computation ; dynamic treatment regime ; potential outcomes
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Abstract:
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The Lower Tidal Volume Ventilation (LTVV) approach is a dynamic treatment regime using volume- and pressure-limited mechanical ventilation for patients with Acute Lung Injury (ALI). We used G-Computation (Lok et al., 2004) to estimate the potential survival function of the LTVV approach among ALI patients in an ARDSNetwork clinical trial (ARDSNetwork, 2000). Our results demonstrate that strict adherence to LTVV is efficacious at reducing short-term mortality.
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