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Activity Number:
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231
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 8, 2006 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307650 |
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Title:
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Scope of the Problem, Options Available, and Empirical Performance of Techniques for Handling Missing Data in Randomized Clinical Trials: Focus on Weight Loss Trials
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Author(s):
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David B. Allison*+
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Companies:
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The University of Alabama at Birmingham
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Address:
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317E RPHB, Birmingham, AL, 35294-0022,
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Keywords:
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Abstract:
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I will provide a brief overview of the theoretical challenge posed by missing data in randomized clinical trials (RCTs), the methods available for analyzing RCTs with missing data, and their a priori specifiable advantages and disadvantages. Using obesity weight loss RCTs as an example, I will present empirical evidence that quantifies the magnitude of the missing data problem, the approaches typically used for addressing it, and differences in results obtained with different methods. Based on this, I will offer inferences about the relative performance of methods in practice and interpretive heuristics.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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