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Activity Number: 494
Type: Topic Contributed
Date/Time: Thursday, August 10, 2006 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #307640
Title: Confidence Levels of Confidence Intervals in the Survival Analysis
Author(s): Xiaolong Shih*+
Companies: Boston Scientific Corporation
Address: One Scimed Place, Maple Grove, MN, 55311,
Keywords: survival analysis ; variance estimate ; confidence interval and simulation
Abstract:

Survival analysis has been used widely in clinical research. In many single-arm trials with objective performance criteria, the one-sided upper or lower confidence limits have been chosen as the only standard in the testing procedure on whether the trial objectives are met. In this presentation, simulation examples will illustrate the performances of several commonly used methods---such as Greenwood, Peto, Dorey, and Korn---in computing the confidence intervals. Also, recommendations of which methods should be used will be made.


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Revised April, 2006