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Activity Number:
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281
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Type:
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Contributed
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Date/Time:
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Tuesday, August 8, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #307627 |
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Title:
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Family-Based Liquid Association Analysis on Atherosclerosis in C3H/HeJ.ApoE-/- x C57BL/6J.ApoE-/- Cross
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Author(s):
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Tun-Hsiang Yang*+ and Ker-Chau Li and Shinsheng Yuan and Aldons J. Lusis and Wei Sun and Susanna Wang
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Companies:
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University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles
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Address:
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11140 Rose Ave., #104, Los Angeles, CA, 90034,
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Keywords:
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liquid association ; allele sharing ; linkage analysis ; ANOVA ; atherosclerotic lesions ; aortic lesions
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Abstract:
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The traditional Linkage Analysis methods have been only modestly successful in identifying genes involved in the disease. The use of the Liquid Association method in conjunction with the idea of the Allele Sharing may improve the ability to identify the candidate genes for the complex disease. Here we propose the Family-based Liquid Association method for the disease genes mapping by taking into account gene interaction effects. Our data came from an F2 intercross between C57BL/6J and C3H/HeJ mice on the ApoE-/- background and fed in a "western" diet for the study of advanced atherosclerotic lesions. Information from a high-density genome scan with 1353 SNPs markers on the quantified aortic lesions trait of all 334 F2 mice is employed. We provide an ANOVA point of view to explain why the genes that mediate most other genes are likely to be linked to the trait.
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